Résumé :
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[BDSP. Notice produite par INIST-CNRS FR0xkEFB. Diffusion soumise à autorisation]. The authors investigated the association between age at menarche and risk of type 2 diabetes mellitus (T2DM) among 101,415 women from the Nurses'Health Study (NHS) aged 34-59 years (1980-2006) and 100,547 women from Nurses'Health Study II (NHS II) aged 26-46 years (1991-2005). During 2,430,274 and 1,373,875 person-years of follow-up, respectively, 7,963 and 2,739 incident cases of T2DM were documented. Young age at menarche was associated with increased risk of T2DM after adjustment for potential confounders, including body figure at age 10 years and body mass index (BMI ; weight (kg)/height (m) 2) at age 18 years. Relative risks of T2DM across age-at-menarche categories (=15 years) were 1.18 (95% confidence interval (CI) : 1.10,1.27), 1.09 (95% CI : 1.02,1.17), 1.00 (referent), 0.92 (95% CI : 0.83,1.01), and 0.95 (95% CI : 0.84,1.06), respectively, in the NHS (P for trend
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