Résumé :
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[BDSP. Notice produite par INIST-CNRS 80nR0x2m. Diffusion soumise à autorisation]. The authors conducted a population-based case-control study of 832 endometrial cancer cases and 846 frequency-matched controls in Shanghai, China (1997-2001), to examine the association of overall adiposity and body fat distribution with disease risk. Overall adiposity was estimated using weight and body mass index (BMI) ; upper body fat distribution was evaluated using waist circumference and waist : hip ratio. Overall and upper-body obesity were both associated with an elevated risk of endometrial cancer. Adjusted odds ratios and 95% confidence intervals for highest-versus-lowest quartile comparisons were 2.6 (95% confidence interval (Cl) : 2.0,3.5) for weight, 2.9 (95% Cl : 2.2,3.9) for BMI, 4.7 (95% Cl : 3.4,6.4) for waist circumference, and 3.5 (95% Cl : 2.6,4.8) for waist : hip ratio. The positive associations with weight and BMI vanished after results were controlled for waist circumference, while associations with waist circumference and waist : hip ratio persisted after adjustment for BMI. The positive association with upper-body obesity was more pronounced among younger women, women who had never used oral contraceptives, and women with a history of diabetes mellitus (p for multiplicative interaction
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