Titre : | Risk factors for autism : Perinatal factors, parental psychiatric history, and socioeconomic status. Commentary. (2005) |
Auteurs : | Heidi-Jeanet LARSSON ; Esben AGERBO ; Preben BO MORTENSEN ; Stephen-R COLE, disc. ; William-W EATON ; Kreesten-Meldgaard MADSEN ; Craig-J NEWSCHAFFER, disc. ; Anne-Vingaard OLESEN ; Diana SCHENDEL ; Poul THORSEN ; Mogens VESTERGAARD ; University of Aarhus. Department of Epidemiology and Social Medicine. Aarhus. DNK ; University of Aarhus. Department of Epidemiology and Social Medicine. North Atlantic Neuro-Epidemiology Alliances. Aarhus. DNK ; University of Aarhus. National Centre for Register-based Research. Aarhus. DNK |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 161, n° 10, 2005) |
Pagination : | 916-928 |
Langues: | Anglais |
Mots-clés : | Facteur risque ; Autisme ; Nouveau né ; Homme ; Facteur socioéconomique ; Parent ; Etude critique ; Foetus ; Psychopathologie ; Femme ; Femme enceinte ; Grossesse ; Pronostic ; Evolution ; Epidémiologie ; Trouble développement ; Hérédité |
Résumé : | [BDSP. Notice produite par INIST-CNRS qR0xnqqO. Diffusion soumise à autorisation]. Research suggests that heredity and early fetal development play a causal role in autism. This case-control study explored the association between perinatal factors, parental psychiatric history, socioeconomic status, and risk of autism. The study was nested within a cohort of all children born in Denmark after 1972 and at risk of being diagnosed with autism until December 1999. Prospectively recorded data were obtained from nationwide registries in Denmark. Cases totaled 698 children with a diagnosis of autism ; each case was individually matched by gender, birth year, and age to 25 controls. Analyses by conditional logistic regression produced risk ratios and 95% confidence intervals. Adjusted analyses showed that the risk of autism was associated with breech presentation (risk ratio (RR)=1.63,95% confidence interval (Cl) : 1.18,2.26), low Apgar score at 5 minutes (RR=1.89,95% Cl : 1.10,3.27), gestational age at birth |