Résumé :
|
[BDSP. Notice produite par INIST-CNRS R0xfq4V7. Diffusion soumise à autorisation]. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial. The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677Tand A 1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses : 16 studies, 2,727 cases and 4,640 controls for C677Tand seven studies, 1,223 cases and 2,015 controls for A 1298C ; pooled analyses : nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C). An increased risk was found for MTHFR677 TTin the meta-analysis (odds ratio (OR)=1.52,95% confidence interval (Cl) : 1.31,1.77) and pooled analysis (OR=1.49,95% Cl : 1.14,1.95). No association resulted for MTHFR 1298 CC (meta-OR=0.94,95% Cl : 0.65,1.35 ; pooled OR=0.90,95% Cl : 0.69,1.34). Results from the pooled analysis of four studies on C677T stratified according to folate levels showed an increased risk for individuals with low (OR=2.05,95% Cl : 1.13,3.72) versus high (OR=0.95,95% Cl : 0.54,1.67) folate levels. Overall, these findings support the hypothesis that folate plays a role in gastric carcinogenesis.
|