Résumé :
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[BDSP. Notice produite par INIST-CNRS ek3R0x54. Diffusion soumise à autorisation]. The authors performed a systematic review and meta-analysis to determine the effect of polymorphisms in genes encoding glutathione S-transferases (GSTs), phase II isoenzymes involved in cellular detoxification, on risk of hepatocellular carcinoma (HCC). Fifteen eligible studies were identified : 14 evaluated GSTM1 ; 13, GSTT1 ; three, GSTP1 ; and one each evaluated GSTM2, GSTM3, GSTA1, GSTA4, GSTO1, and GST02, respectively. All were case-control studies performed in populations with high (Asian, African) and medium (European) HCC incidence rates. Random-effects meta-analyses suggested a small excess risk of HCC with GSTT1 null (odds ratio (OR)=1.19,95% confidence interval (Cl) : 0.99,1.44) and possibly GSTM1 null (OR=1.16,95% Cl : 0.89,1.53) genotypes. Cumulative meta-analyses demonstrated that both pooled estimators generally trended toward a small excess risk with publication of more recent studies. Results for GSTP1 A313G suggested no excess risk (OR=0.75,95% Cl : 0.50,1.15). A number of potentially interesting gene-gene and gene-environment interactions were reported, but these were too few and inconsistent to allow meta-analysis. The overall results suggest that there may be a small excess risk of HCC in individuals with GSTT1 null and possibly also with GSTM1 null genotypes. However, given the relatively limited total number of subjects examined and observed between-study heterogeneity, chance could not be excluded.
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