Titre : | No association between body size at birth and leucocyte telomere length in adult life-evidence from three cohort studies. (2012) |
Auteurs : | Eero KAJANTIE ; Sture ANDERSSON ; ERIKSSON (Johan-G) : FIN. Helsinki University Central Hospital. Unit of General Practice. Helsinki. ; Iiris HOVATTA ; Petteri HOVI ; Laura KANANEN ; Jaakko KAPRIO ; Kirsi-H PIETILAINEN ; RAIKKONEN (Katri) : FIN. Department of Behavioral Sciences. University of Helsinki. Helsinki. ; Alia RISSANEN ; Karoliina WEHKALAMPI ; Children's Hospital. Helsinki University Central Hospital and University of Helsinki. Helsinki. FIN ; Department of Medical Genetics. Haartman Institute. University of Helsinki. Helsinki. FIN ; Institute for Molecular Medicine Finland Fimm Helsinki. FIN ; Obesity Research Unit. Helsinki University Central Hospital. Helsinki. FIN ; Research Programs Unit. Molecular Neurology. Biomedicum Helsinki. University of Helsinki. Helsinki. FIN ; Twin Research Unit. Hjelt Institute. University of Helsinki. Helsinki. FIN |
Type de document : | Article |
Dans : | International journal of epidemiology (vol. 41, n° 5, 2012) |
Pagination : | 1400-1408 |
Langues: | Anglais |
Mots-clés : | Association ; Taille corporelle ; Leucocyte ; Adulte ; Poids naissance ; Prématurité ; Homme ; Vieillissement |
Résumé : | [BDSP. Notice produite par INIST-CNRS lsl8lR0x. Diffusion soumise à autorisation]. Background Shorter leucocyte telomere length (LTL) is a promising marker of biological ageing. It is predicted by cumulative adverse conditions throughout life course, but few studies have data from the prenatal period when most developmental processes and cell replication take place. We studied whether body size at birth and underlying factors including severely preterm birth predict LTL in adult life. Methods We used data from following three cohorts : (i) 1894 subjects (age : 56-69 years) from the Helsinki Birth Cohort Study (HBCS), representing normal variation in fetal growth ; (ii) the Helsinki Study of Very Low Birth Weight Adults encompassing 164 subjects born preterm at very low birthweight ( |