Titre : | The placental origins of sudden cardiac death. (2012) |
Auteurs : | BARKER (David-Jp) : SAU. Chair of Fetal Programming. Zoology Department. College of Science. King Saud University. Riyadh. ; ERIKSSON (Johan-G) : FIN. Department of General Practice and Primary Health Care. Institute of Clinical Medicine. University of Helsinki. Helsinki. ; KAJANTIE (Eero) : FIN. Hospital for Children and Adolescents. Helsinki University Central Hospital. Helsinki. ; Gail LARSEN ; Clive OSMOND ; Kent-L THORNBURG ; Heart Research Center and Moore Institute. Oregon Health and Science University. Portland. OR. USA ; Mrc Lifecourse Epidemiology Unit. University of Southampton. Southampton General Hospital. Southampton Hampshire. GBR |
Type de document : | Article |
Dans : | International journal of epidemiology (vol. 41, n° 5, 2012) |
Pagination : | 1394-1399 |
Langues: | Anglais |
Mots-clés : | Placenta ; Mort subite ; Grossesse ; Niveau enseignement ; Facteur sociodémographique |
Résumé : | [BDSP. Notice produite par INIST-CNRS mrn8R0xl. Diffusion soumise à autorisation]. Objective Most sudden cardiac deaths are due to cardiac arrhythmias, and abnormalities in the autonomic nervous system could underlie them. There is growing evidence that coronary heart disease is associated with alterations of fetal development as a result of variations in the processes of placentation that control fetal nutrition. We hypothesized that placental size would be associated with sudden cardiac death. Methods We examined sudden cardiac death within the Helsinki Birth Cohort of 13 345 men and women. Results One hundred eighty-seven (2.7%) men and 47 (0.7%) women had sudden unexplained cardiac death outside hospital. Sudden death was associated with a thin placenta, the hazard ratio being 1.47 [95% confidence interval (CI) 1.11-1.93, P=0.006] for each g/cm2 decrease in thickness. Sudden death was independently associated with poor educational attainment (P |