Résumé :
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[BDSP. Notice produite par INIST-CNRS lCR0xt78. Diffusion soumise à autorisation]. Prospective epidemiologic data on the association between vitamin D and mortality are limited, particularly in Asian populations. Among subjects in Linxian, China, the authors aimed to test whether baseline serum 25-hydroxyvitamin D (25 (OH) D) concentrations in a prospective cohort were associated with all-cause mortality and cause-specific mortality rates over 24 years of follow-up (1986-2010). Serum 25 (OH) D concentrations were measured in 1,101 subjects using an immunoassay. Hazard ratios and 95% confidence intervals were calculated using Cox regression models that were adjusted for age, sex, tobacco smoking, alcohol drinking, and hypertension. The 25th, 50th, and 75th percentile concentrations of 25 (OH) D were 19.6,31.9, and 48.4 nmol/L, respectively. During follow-up, 793 subjects died, including 279 who died of cerebrovascular accident, 217 who died of cancer, and 200 cardiovascular disease deaths. All-cause mortality was not associated with 25 (OH) D concentrations using continuous models (for every 15 nmol/L, hazard ratio=1.01,95% confidence interval : 0.97,1.05) or quartile models (fourth vs. first quartiles, hazard ratio=1.06,95% confidence interval : 0.87,1.30 ; P for trend=0.731). The authors also found no association with the cause-specific mortality outcomes. Results were similar for men and women. This study showed that prediagnostic serum 25 (OH) D concentrations were not associated with all-cause or cause-specific mortality rates in this Chinese population who had low levels of vitamin D.
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