Titre : | The Tulane University School of Public Health and Tropical Medicine 100th Anniversary Issue. Sickle Cell Trait Protects Against Plasmodium falciparum Infection. (2012) |
Auteurs : | Mounkaila-A BILLO ; Pierre BUEKENS ; Mahamadou DIAKITE ; Mouctar DIALLO ; Sory-I DIAWARA ; Seydou-O DOUMBIA ; Ogobara-K DOUMBO ; Mark-A JAMES ; Eric-S JOHNSON ; Donald-J KROGSTAD ; Belco POUDIOUGOU ; Janet RICE ; Issaka SAGARA ; Anatole TOUNKARA ; Department of Epidemiology. Health Sciences Center. Tulane University. New Orleans. LA. USA ; Department of the Epidemiology of Parasitic Diseases. University of Mali. Bamako. MLI ; Department of Tropical Medicine. Health Sciences Center. Tulane University. New Orleans. LA. USA ; Mali-Tulane Tropical Medicine Research Center. Malaria Research and Training Center. Bamako. MLI |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 176, n° 7, 2012) |
Pagination : | S175-S185 |
Langues: | Anglais |
Mots-clés : | Paludisme ; Protection ; Epidémiologie ; Parasitose ; Infection ; Protozoaire ; Hémoglobinopathie ; Hémopathie ; Maladie héréditaire |
Résumé : | [BDSP. Notice produite par INIST-CNRS IrR0xItA. Diffusion soumise à autorisation]. Although sickle cell trait protects against severe disease due to Plasmodium falciparum, it has not been clear whether sickle trait also protects against asymptomatic infection (parasitemia). To address this question, the authors identified 171 persistently smear-negative children and 450 asymptomatic persistently smear-positive children in Bancoumana, Mali (June 1996 to June 1998). They then followed both groups for 2 years using a cohort-based strategy. Among the 171 children with persistently negative smears, the median time for conversion to smear-positive was longer for children with sickle trait than for children without (274 vs. 108 days, P |