Titre : | Vitamin K and Vitamin D Status : Associations with Inflammatory Markers in the Framingham Offspring Study. (2008) |
Auteurs : | M. KYLA SHEA ; BENJAMIN (Emelia-J) : USA. Department of Epidemiology. School of Public Health. Boston University. Boston. MA. ; Sarah-L BOOTH ; Ralph-Bsr D'AGOSTINO ; Bess DAWSON-HUGHES ; Paul-F JACQUES ; Sekar KATHIRESAN ; John-Fjr KEANEY ; MASSARO (Joseph-M) : USA. Department of Biostatistics. School of Public Health. Boston University. Boston. MA. ; Christopher-J O'DONNELL ; Jose-M ORDOVAS ; Ramachandran-S VASAN ; Cardiology and Preventive Medicine Sections. Department of Medicine. School of Medicine. Boston University. Boston. MA. USA ; Department of Mathematics and Statistics. Boston University. Boston. MA. USA ; Department of Medicine. Massachusetts General Hospital. Harvard University. Boston. MA. USA ; Framingham Heart Study. National Heart. Lung. And Blood Institute. Framingham. MA. USA ; Jean Mayer Usda Human Nutrition Research Center on Aging. Tufts University. Boston. MA. USA ; Whitaker Cardiovascular Institute. Boston University Medical Center. Boston. MA. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 167, n° 3, 2008) |
Pagination : | 313-320 |
Langues: | Anglais |
Mots-clés : | Vitamine D ; Vitamine K ; Association ; Inflammation ; Epidémiologie ; Famille descendante ; Homme |
Résumé : | [BDSP. Notice produite par INIST-CNRS a2XzR0xF. Diffusion soumise à autorisation]. In vitro data suggest protective roles for vitamins K and D in inflammation. To examine associations between vitamins K and D and inflammation in vivo, the authors used multiple linear regression analyses, adjusted for age, sex, body mass index, triglyceride concentrations, use of aspirin, use of lipid-lowering medication, season, menopausal status, and hormone replacement therapy. Participants were from the Framingham Offspring Study (1997-2001 ; n=1,381 ; mean age=59 years ; 52% women). Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circulating inflammatory markers as a group and with several individual inflammatory biomarkers (p |