Résumé :
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[BDSP. Notice produite par INIST-CNRS DR0xsopl. Diffusion soumise à autorisation]. Few studies of reproductive hormone exposures and non-Hodgkin lymphoma (NHL) have examined NHL subtypes. Associations between reproductive hormonal factors and risk of all NHL and of two predominant subtypes, diffuse large-cell lymphoma (DLCL) (n=233) and follicular lymphoma (n=173), were investigated among women (n=581) in a large, population-based, case-control study (1,591 cases, 2,515 controls). Controls (n=836) identified by random digit dialing were frequency matched by age and county to incident NHL cases ascertained in the San Francisco Bay Area of California in 1988-1993. Adjusted unconditional logistic regression was used to obtain odds ratios. More than four pregnancies indicated a possible lower risk of all NHL (odds ratio (OR)=0.81,95% confidence interval (Cl) : 0.55,1.2 ; p-trend=0.06) and of DLCL (OR=0.53,95% Cl : 0.31,0.90 ; p-trend=0.01). Exclusive use of menopausal hormone therapy for>=5 years was associated with a reduced risk of all NHL (OR=0.68,95% Cl : 0.48,0.98) and of DLCL (OR=0.50,95% Cl : 0.30,0.85). Oral contraceptive use indicated a lower risk of all NHL (OR=0.68,95% Cl : 0.49,0.94), and perhaps DLCL (OR=0.79,95% Cl : 0.51,1.2), and of follicular lymphoma (OR=0.75,95% Cl : 0.46,1.2). Results suggest that endogenous and exogenous reproductive hormones confer different risks by NHL subtype and are associated with a reduced risk of DLCL in women.
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