Résumé :
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[BDSP. Notice produite par INIST-CNRS R0x04ghI. Diffusion soumise à autorisation]. Factors that influence circulating sex hormones, such as physical activity, have been proposed to influence ovarian cancer risk ; however, results from previous epidemiologic studies have been inconsistent. The authors examined the association among physical activity, sedentary behavior, and ovarian cancer risk in the American Cancer Society Cancer Prevention Study II Nutrition Cohort, a prospective study of cancer incidence and mortality, using information obtained at baseline in 1992. From 1992 to 2001,314 incident ovarian cancer cases were identified among 59,695 postmenopausal women who were cancer free at enrollment. Cox proportional hazards modeling was used to compute hazard rate ratios while adjusting for potential confounders. No overall association was observed between measures of past physical activity or with recreational physical activity at baseline and risk of ovarian cancer in this study (for the highest category of physical activity compared with none : hazard rate ratio=0.73,95% confidence interval : 0.40,1.34). However, a prolonged duration of sedentary behavior was associated with an increased risk (for>6 vs.
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