Résumé :
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[BDSP. Notice produite par INIST-CNRS WR0xgMKc. Diffusion soumise à autorisation]. The authors examined whether a serum pepsinogen test (SPT) based on the combination of the serum pepsinogen I level and pepsinogen I/II ratio is a good predictor of gastric cancer occurrence in a general Japanese population. A total of 2,446 subjects aged>40 years were classified into negative, positive, and strong-positive SPT groups and were followed prospectively for 14 years (1988-2002). Compared with that for the negative SPT group (26 men, 10 women), gastric cancer incidence increased significantly for both men (n=17 ; age-adjusted hazard ratio=4.56,95% confidence interval : 2.42,8.60) and women (n=6 ; age-adjusted hazard ratio=5.84,95% confidence interval : 2.00,17.11) in the strong-positive SPT group. It was also significantly higher in the positive SPT group for men (n=23 ; age-adjusted hazard ratio=3.91,95% confidence interval : 2.23,6.86). These associations did not attenuate even after adjustment for other comprehensive risk factors. Stratified analysis revealed significant associations between the SPT and development of intestinal-type gastric cancer as well as of cancer in both Helicobacter pylori-negative and - positive subjects. These findings suggest that the SPT can serve as a predictor of intestinal-type gastric cancer, irrespective of H. pylori infection.
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