Résumé :
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[BDSP. Notice produite par INIST-CNRS 3YKR0x46. Diffusion soumise à autorisation]. Using data from the current National Health and Nutrition Examination Survey (1999-2000), the authors assessed whether Helicobacter pylori infection is associated with iron deficiency and iron-deficiency anemia (IDA) in the United States. Iron deficiency was defined as at least two abnormal results out of three biomarkers of iron stores. IDA was defined as a low hemoglobin level in the presence of iron deficiency. H. pylori infection was measured by serology. Complex survey estimators were used in the analysis. For 7,462 survey participants aged>3 years, H. pylori infection was associated with decreased serum ferritin levels (percent change=-13.9%, 95% confidence interval (Cl) : - 19.5, - 8.0) but not with levels of free erythrocyte protoporphyrin, transferrin saturation, or hemoglobin (percent change=1.5%, - 2.8%, and - 1.1%, respectively). Multinomial logistic regression analyses indicated that H. pylori infection was associated with the prevalence of IDA (prevalence odds ratio (POR)=2.6,95% Cl : 1.5,4.6) and, to a lesser degree, other types of anemia (POR=1.3,95% Cl : 1.0,1.7). H. pylori infection was associated with a 40% increase in the prevalence of iron deficiency (POR=1.4,95% Cl : 0.9,2.0) after controlling for relevant covariates. In the United States, H. pylori infection was associated with iron deficiency/IDA regardless of the presence or absence of peptic ulcer disease.
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