Résumé :
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[BDSP. Notice produite par INIST-CNRS R9R0xa1k. Diffusion soumise à autorisation]. Findings on the role of thrombophilic polymorphisms in adverse pregnancy outcomes, particularly intrauterine growth restriction, are inconsistent. Such inconsistencies may be partly due to two types of effects which have not been considered before with regard to thrombophilic genes : parent-of-origin effects (imprinting) and transmission-ratio distortion effects (allele transmission differing from that expected in unaffected subjects). In this study of infants born at a Canadian hospital (1998-2000), the authors investigated both types of effects. Cases (n=493) were defined as newborns whose birth weight for gestational age and sex was below the 10th percentile by national standards, and controls (n=472) as newborns at or above the 10th percentile. Log-linear models were used to analyze the transmission of variant alleles among case-and control-parent trios. A single copy of a common polymorphism, Val34Leu in factor XIII, increased the risk of intrauterine growth restriction approximately 70% when the parent of origin was the father as opposed to the mother (p
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