Résumé :
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[BDSP. Notice produite par INIST-CNRS AJsCR0x8. Diffusion soumise à autorisation]. The authors assess the ability of toenail nicotine levels as a biomarker to predict incident coronary heart disease (CHD). A nested case-control study was carried out among 62,641 women aged 36-61 years in the Nurses'Health Study cohort who provided toenail clippings in 1982. Between 1984 and 1998,905 incident CHD cases were diagnosed and matched with two controls by age and date of toenail collection. Using multivariate logistic regression analyses, the authors found a statistically significant dose-response association between increasing toenail nicotine levels and risk of CHD (ptrend
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