Résumé :
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[BDSP. Notice produite par INIST-CNRS onrR0xGJ. Diffusion soumise à autorisation]. The incidence and mortality of acute myocardial infarction (AMI) remain low in Japan despite major dietary changes and worsening cardiovascular risk factors, a situation that should have resulted in a substantial increase in AMI rates (Japanese paradox). The current trend in the incidence of AMI was examined for the period 1990-2001 by use of data from the Takashima AMI Registry covering a stable population of approximately 55,000 in central Japan. AMI incidence rates (per 100,000 person-years) and 95% confidence intervals were calculated for 1990-1992,1993-1995,1996-1998, and 1999-2001. The incidence trend was determined by calculating the average annual change in percentage across the years. There were 352 (men : n=224 ; women : n=128) registered first-ever AMI cases during 1990-2001. The age-adjusted incidence rate of all AMI showed a gradual increase from 39.9 (95% confidence interval (Cl) : 29.8,50.0) in 1990-1992 to 62.6 (95% Cl : 51.5,73.7) in 1999-2001. In men, the age-adjusted incidence rate increased from 66.5 (95% Cl : 46.4,86.6) in 1990-1992 to 100.7 (95% Cl : 78.6,122.7) in 1999-2001. In women, fluctuation was observed after an initial steep increase. The average annual incidence increased by 7.6% (95% Cl : 3.5,11.7) among men and by 8.3% (95% Cl : 1.02,15.6) among women. To the best of the authors'knowledge, this is the first study to report an increasing trend of AMI in a Japanese population.
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