Résumé :
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[BDSP. Notice produite par INIST-CNRS 8HrmR0xr. Diffusion soumise à autorisation]. In this study, the authors sought to determine whether single nucleotide polymorphisms in the estrogen receptor alpha (ESR1) and matrix metalloproteinase 2 (MMP2) genes are associated with age-related maculopathy (ARM) in older women. Subjects comprised a random sample of Caucasian women aged>74 years participating in the Study of Osteoporotic Fractures year 10 follow-up (n=906) in 1997-1998. Fundus photographs were graded for ARM using a modification of the Wisconsin Age-Related Maculopathy Grading System. The prevalences of early ARM and late ARM were 46% and 4%, respectively. The MMP2 rs2287074 single nucleotide polymorphism (G-A) was associated with ARM. The A allele was present in 47%, 43%, and 30% of subjects with no, early, and late ARM, respectively (p=0.01), and was associated with lower odds of any ARM (for AG vs. GG, odds ratio=0.80,95% confidence interval : 0.65,0.99 ; for AA vs. GG, odds ratio=0.64,95% confidence interval : 0.42,0.98). An interaction with use of postmenopausal hormone therapy was significant (p=0.02). The MMP2 rs2287074 A allele may be associated with a lower likelihood of ARM in older Caucasian women, particularly those who have never used hormone therapy. The role of MMP2 rs2287074 in ARM should be further elucidated.
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