Résumé :
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[BDSP. Notice produite par INIST-CNRS HCEkCR0x. Diffusion soumise à autorisation]. High-dose p-carotene supplementation in high-risk persons has been linked to increased lung cancer risk in clinical trials ; whether effects are similar in the general population is unclear. The authors examined associations of supplemental p-carotene, retinol, vitamin A, lutein, and lycopene with lung cancer risk among participants, aged 50-76 years, in the VITamins And Lifestyle (VITAL) cohort Study in Washington State. In 2000-2002, eligible persons (n=77,126) completed a 24-page baseline questionnaire, including detailed questions about supplement use (duration, frequency, dose) during the previous 10 years from multivitamins and individual supplements/mixtures. Incident lung cancers (n=521) through December 2005 were identified by linkage to the Surveillance, Epidemiology, and End Results cancer registry. Longer duration of use of individual p-carotene, retinol, and lutein supplements (but not total 10-year average dose) was associated with statistically significantly elevated risk of total lung cancer and histologic cell types ; for example, hazard ratio=2.02,95% confidence interval : 1.28,3.17 for individual supplemental lutein with total lung cancer and hazard ratio=3.22,95% confidence interval : 1.29,8.07 for individual p-carotene with small-cell lung cancer for>4 years versus no use. There was little evidence for effect modification by gender or smoking status. Long-term use of individual p-carotene, retinol, and lutein supplements should not be recommended for lung cancer prevention, particularly among smokers.
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