Titre :
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Effect of Formal Statistical Significance on the Credibility of Observational Associations. Commentary. Author's reply. (2008)
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Auteurs :
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IOANNIDIS (John-Pa) : GRC. Clinical and Molecular Epidemiology Unit. Department of Hygiene and Epidemiology. University of Ioannina School of Medicine. Ioannina. ;
KATKI (Hormuzd-A) / disc. : USA. Division of Cancer Epidemiology and Genetics. National Cancer Institute. Rockville. MD.
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 168, n° 4, 2008)
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Pagination :
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374-390
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Langues:
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Anglais
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Mots-clés :
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Association
;
Epidémiologie
;
Statistique
;
Homme
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Résumé :
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[BDSP. Notice produite par INIST-CNRS p9qR0xm7. Diffusion soumise à autorisation]. The author evaluated the implications of nominal statistical significance for changing the credibility of null versus alternative hypotheses across a large number of observational associations for which formal statistical significance (p0.10) for 54-77% of the 272 epidemiologic associations for diverse risk factors and 44-70% of the 50 associations from genetic meta-analyses. Sometimes nominally statistically significant results even decreased the credibility of the probed association in comparison with what was thought before the study was conducted. Five of six meta-analyses with less than substantial support (B>0.032) lost their nominal statistical significance in a subsequent (more recent) meta-analysis, while this did not occur in any of seven meta-analyses with decisive support (B
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