Titre :
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Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls : discrepancies between genotype, blood lipid concentrations, and coronary disease risk : Genetic epidemiology. (2004)
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Auteurs :
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KEAVNEY (Bernard) : GBR. Institute of Human Genetics. University of Newcastle-upon-Tyne. ;
Sarah CLARK ;
Rory COLLINS ;
DANESH (John) : GBR. Department of Public Health. University of Cambridge. ;
Marc DELEPINE ;
Mark LATHROP ;
MCKENZIE (Colin) : JAM. Tropical Metabolism Research Unit. University of the West Indies. Kingston. ;
Alison PALMER ;
Sarah PARISH ;
Richard PETO ;
Linda YOUNGMAN ;
International Studies of Infarct Survival Collaborators. (I.S.S.I.). INT ;
University of Oxford. Nuffield Department of Clinical Medicine. Clinical Trial Service Unit and Epidemiological Studies Unit. GBR
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 33, n° 5, 2004)
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Pagination :
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1002-1013
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Langues:
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Anglais
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Mots-clés :
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Cardiopathie coronaire
;
Facteur risque
;
Epidémiologie
;
Lipide
;
Plasma sanguin
;
Royaume Uni
;
Europe
;
Homme
;
Gène
;
Appareil circulatoire [pathologie]
;
Myocarde [pathologie]
;
Génétique
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Résumé :
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[BDSP. Notice produite par INIST-CNRS 84nt1R0x. Diffusion soumise à autorisation]. Background : Blood lipid concentrations are causally related to the risk of coronary heart disease (CHD). Various associations between CHD risk and genes that moderately affect plasma lipid levels have been described, but previous studies have typically involved too few'cases'to assess these associations reliably. Methods : The present study involves 4685 cases of myocardial infarction (MI) and 3460 unrelated controls without diagnosed cardiovascular disease. Six polymorphisms of four'lipid-related'genes were genotyped. Results : For the apolipoprotein E epsilon2/epsilon3/epsilon4 polymorphism, the average increase in the plasma ratio of apolipoprotein B to apolipoprotein A1 (apoB/apoA1 ratio) among controls was 0.082 (s.e. 0.007) per stepwise change from epsilon3/epsilon2 to epsilon3/epsilon3 to epsilon3/epsilon4 genotype (trend P
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