Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xHZlp3. Diffusion soumise à autorisation]. To examine effects of body size change on postmenopausal breast cancer, the authors conducted a population-based case-control study among 990 cases and 1,006 controls participating in the Long Island Breast Cancer Study Project in 1996-1997. Women who had gained more than 15 kg (33 pounds) since age 20 years were at a 1.6-fold increased risk of breast cancer (95% confidence interval (Cl) : 1.11,2.26) relative to their counterparts with stable (+/-3 kg) weight. Subjects who had gained more than 11 kg (24 pounds) during the peri-and postmenopausal years (since age 50 years) had 1.62 times the risk of breast cancer of those whose weight remained unchanged during this time period. This effect of peri-and postmenopausal body size gain was present only among never users of hormone replacement therapy (odds ratio (OR)=2.02 (95% Cl : 1.35,3.02) as opposed to 0.81 (95% Cl : 0.43,1.53) for ever users ; multiplicative interaction : p
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