Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xSA87t. Diffusion soumise à autorisation]. The authors performed a meta-analysis of 33 studies examining the association of type 1 diabetes mellitus with polymorphisms in the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene, including the A49G (29 comparisons), C (-318) T (three comparisons), and (AT) n microsatellite (six comparisons) polymorphisms. The studies included 5,637 cases of type 1 diabetes and 6,759 controls (4,775 and 5,829, respectively, for analysis of the A49G polymorphism). The random-effects odds ratio for the *G (Ala) allele versus the *A (Thr) allele was 1.45 (95% confidence interval (Cl) : 1.28,1.65), with significant between-study heterogeneity (p
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