Résumé :
|
[BDSP. Notice produite par INIST-CNRS WR0xhmmZ. Diffusion soumise à autorisation]. Aims : The purpose was to study the association of a single serum cholesterol measurement with early and late coronary and other cardiovascular deaths during 35 years of follow-up in samples of men aged 40-59 years in five European countries. Methods and results : A single serum total cholesterol measurement was considered in samples from Finland (N=1563), the Netherlands (N=811), Italy (N=1642), Serbia (N=1537) and Greece (N=1158) (total=6711). Seven partitioned proportional hazards models were solved, one for each of seven independent 5-year blocks, to predict coronary, stroke, cardiovascular disease and all-cause mortality risk. Partitioned hazard scores were cumulated. The resulting curves showed a relatively constant strength in risk for coronary deaths as a function of baseline serum cholesterol levels, although a strong relationship during the first 10-year period was followed by a weaker relationship later on. The pooled estimates for the five countries gave a relative risk for 1 mmol/l of serum cholesterol (95% confidence intervals) of 1.44 (1.23-1.68) for the first period ; 1.52 (1.31-1.76) for the second period ; and 1.16 (1.02-1.32) for the third period ; 1.18 (1.05-1.32) for the forth period ; 1.17 (1.05-1.31) for the fifth period ; 1.22 (1.10-1.35) for the sixth period ; 1.18 (1.05-1.32) for the seventh 5-year period of follow-up. No significant relationship were found between serum cholesterol and stroke and all-cause mortality, while intermediate findings were obtained for cardiovascular diseases. Conclusion : A single serum cholesterol measurement in middle aged-men maintains a strong relationship with the occurrence of coronary heart disease (CHD) deaths during 35 years of follow-up.
|