Résumé :
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[BDSP. Notice produite par INIST-CNRS 1gL4JR0x. Diffusion soumise à autorisation]. BACKGROUND : The presence of Human Herpesvirus-8 (HHV8) DNA is predictive of Kaposi sarcoma (KS) among patients with HIV-associated or iatrogenic immunosuppression. However, correlates of HHV8-DNA detection in the general population remain undefined. METHODS : We assessed correlates of HHV8-DNA detection among Italian adults without KS who had antibodies against HHV8-latent nuclear antigen by immunofluorescence assay. HHV8-K6 DNA sequences were detected in peripheral blood mononuclear cells using TaqMan PCR. RESULTS : Of the 158 subjects 26 (16.5%) had detectable HHV8-DNA [median copies/million cells, 53 ; (13-2128) ]. Adjusted for age, sex, and laboratory, HHV8-DNA was detected more frequently in participants with>7 total residents in the childhood home [OR=3.7 (1.5-9.1) ],>2 younger siblings [OR=2.6 (1.1-6.5) ], and current cardiovascular [OR=3.6 (1.3-9.7) ] or renal [OR=3.1 (1.2-8.0) ] disease. Excluding the participants using immune modulating drugs, HHV8-DNA was more frequent among those with low red blood cells (RBC) [92 microm3/red cell ; OR=2.8 (1.0-7.8) ], and mild thrombocytopenia [
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