Résumé :
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[BDSP. Notice produite par INIST-CNRS GR0xh3UE. Diffusion soumise à autorisation]. The association of antioxidant vitamins and trace elements from foods and supplements with risk of rheumatoid arthritis was evaluated in a prospective cohort study of 29,368 women who were aged 55-69 years at baseline in 1986. Through 1997,152 cases of rheumatoid arthritis were identified. After controlling for other risk factors, greater intakes (highest tertile vs. lowest) of supplemental vitamin C (relative risk (RR)=0.70,95% confidence interval (Cl) : 0.48,1.09 ; p-trend=0.08) and supplemental vitamin E (RR=0.72,95% Cl : 0.47,1.12 ; p-trend=0.06) were inversely associated with rheumatoid arthritis. There was no association with total carotenoids, alpha-or bêta-carotene, lycopene, or lutein/zeaxanthin, while there was an inverse association with bêta-cryptoxanthin (RR=0.59,95% Cl : 0.39,0.90 ; p-trend=0.01). Greater use of supplemental zinc (RR=0.39,95% Cl : 0.17,0.88 ; p-trend=0.03) was inversely associated with rheumatoid arthritis, while any use of supplemental copper (RR=0.54,95% Cl : 0.28,1.03) and manganese (RR=0.50,95% Cl : 0.23,1.07) showed suggestive inverse associations with rheumatoid arthritis. Greater intakes of fruit (RR=0.72,95% Cl : 0.46,1.12 ; p-trend=0.13) and cruciferous vegetables (RR=0.65,95% Cl : 0.42,1.01 ; p-trend=0.07) also exhibited trends toward inverse associations with risk. When the antioxidants were modeled together, only bêta-cryptoxanthin and supplemental zinc were statistically significant predictors. Intake of certain antioxidant micronutrients, particularly bêta-cryptoxanthin and supplemental zinc, and possibly diets high in fruits and cruciferous vegetables, may be protective against the development of rheumatoid arthritis.
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