Résumé :
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[BDSP. Notice produite par INIST-CNRS 79mFlR0x. Diffusion soumise à autorisation]. Use of analgesics is common and is associated with increased risk of hearing loss in men ; however, the relation has not been examined prospectively in women. The authors prospectively examined the relation between frequency of aspirin, ibuprofen, and acetaminophen use and risk of hearing loss among 62,261 women aged 31-48 years at baseline (1995) in Nurses'Health Study II. The outcome was self-reported hearing loss (n=10,012), and the follow-up period was 1995-2009. Cox proportional hazards regression was used to adjust for potential confounders. During 764,247 person-years of follow-up, ibuprofen use and acetaminophen use were independently associated with increased risk of hearing loss, but aspirin use was not. For ibuprofen, the multivariate-adjusted relative risk of hearing loss was 1.13 (95% confidence interval (CI) : 1.06,1.19) for use 2-3 days/week, 1.21 (95% CI : 1.11,1.32) for use 4-5 days/week, and 1.24 (95% CI : 1.14,1.35) for use>=6 days/week (P-trend
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