Résumé :
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[BDSP. Notice produite par INIST-CNRS R0x02jEK. Diffusion soumise à autorisation]. Background : Blood concentrations of fibrinogen have been associated with coronary heart disease risk in epidemiological studies, but it is uncertain whether this association is causal or reflects residual confounding by other risk factors. We investigated the relationship between the single nucleotide polymorphism at position - 148 in the beta-fibrinogen gene promoter (bêta - 148C/T), blood fibrinogen levels, and risk of myocardial infarction (MI) in sufficiently large numbers of coronary disease cases to reliably address this question. Methods : Genotyping and measurement of blood fibrinogen concentration were carried out in 4685 cases of confirmed MI and 3460 controls with no history of coronary disease. A meta-analysis of ISIS and 19 other studies of beta-fibrinogen genotypes involving a total of 12 220 coronary disease cases and 18716 controls was conducted. Results : Among the ISIS controls, mean plasma fibrinogen concentrations with the C/C, C/T and T/T genotypes were 3.34 (SE 0.015), 3.48 (0.022), and 3.60 (0.064) g/l, respectively, corresponding to an increase of 0.14 (0.024) g/l per T allele (trend P
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