Résumé :
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[BDSP. Notice produite par INIST-CNRS O9PR0x73. Diffusion soumise à autorisation]. The authors prospectively evaluated fruit and vegetable consumption and the incidence of oral premalignant lesions among 42,311 US men in the Health Professionals Follow-up Study. Diet was assessed every 4 years by food frequency questionnaires. The authors confirmed 207 cases of clinically or histopathologically diagnosed oral premalignant lesions occurring between 1986 and 2002. Multivariate-adjusted relative risks were calculated from proportional hazards models. Significant inverse associations were observed with citrus fruits, citrus fruit juice, and vitamin-C-rich fruits and vegetables, indicating 30-40% lower risks with greater intakes (e.g., citrus fruit juice quintile 5 vs. quintile 1 relative risk=0.65,95% confidence interval : 0.42,0.99). Inverse associations with fruits did not vary by smoking status and were stronger in analyses of baseline consumption, with a 10-year lag time to disease follow-up (quintile 5 vs. quintile 1 relative risk=0.41,95% confidence interval : 0.20,0.82 ; p=0.01). No associations were observed with total vegetables or with p-carotene-rich or lycopene-rich fruits and vegetables. For current smokers, green leafy vegetables (ptrend=0.05) and bêta-carotene-rich fruits and vegetables (ptrend=0.02) showed significant linear trends of increased risk (one additional serving/day relative risk=1.7). The risk of oral premalignant lesions was significantly reduced with higher consumption of fruits, particularly citrus fruits and juices, while no consistent associations were apparent for vegetables.
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