Titre :
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Apparently conclusive meta-analyses may be inconclusive-Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. (2009)
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Auteurs :
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Jesper BROK ;
Christian GLUUD ;
Kristian THORLUND ;
Jorn WETTERSLEV ;
Copenhagen Trial Unit. Center for Clinical Intervention Research. Copenhagen. DNK
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 38, n° 1, 2009)
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Pagination :
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287-298
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Langues:
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Anglais
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Mots-clés :
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Essai thérapeutique
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Facteur risque
;
Risque
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Dépistage
;
Nouveau né
;
Information
;
Homme
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Résumé :
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[BDSP. Notice produite par INIST-CNRS A7n7R0x9. Diffusion soumise à autorisation]. Background : Random error may cause misleading evidence in meta-analyses. The required number of participants in a meta-analysis (i.e. information size) should be at least as large as an adequately powered single trial. Trial sequential analysis (TSA) may reduce risk of random errors due to repetitive testing of accumulating data by evaluating meta-analyses not reaching the information size with monitoring boundaries. This is analogous to sequential monitoring boundaries in a single trial. Methods : We selected apparently conclusive (P
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