Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xrrnAJ. Diffusion soumise à autorisation]. Oocytes are formed in utero ; menopause occurs when the oocyte pool is depleted. The authors hypothesized that early-life events could affect the number of a woman's oocytes and determine age at menopause. To test their hypothesis, the authors conducted a secondary analysis of baseline data from 22,165 participants in the Sister Study (2003-2007) who were aged 35-59 years at enrollment. To estimate the association between early-life events and age at natural menopause, the authors used Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals, adjusting for current age, race/ethnicity, education, childhood family income, and smoking history. Earlier menopause was associated with in-utero diethylstilbestrol exposure (hazard ratio (HR)=1.45,95% confidence interval (CI) : 1.27,1.65). Suggestive associations included maternal prepregnancy diabetes (HR=1.33,95% CI : 0.89,1.98) and low birth weight (HR=1.09,95% CI : 0.99,1.20). Having a mother aged 35 years or older at birth appeared to be associated with a later age at menopause (HR=0.95,95% CI : 0.89,1.01). Birth order, in-utero smoke exposure, and having been breastfed were not related to age at menopause. In-utero and perinatal events may subsequently influence age at menopause.
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