Résumé :
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[BDSP. Notice produite par INIST-CNRS ER0x9so7. Diffusion soumise à autorisation]. Change and fluctuation in body mass index (BMI ; weight (kg)/height (m) 2) may be associated differently with coronary artery calcification (CAC) than with carotid artery intima-media thickness (IMT). The authors analyzed data on 2,243 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, initially aged 18-30 years, who were examined every 2-5 years over a 20-year period (1985-2006). BMI at year 0 was associated positively and linearly with CAC at year 20 ; however, the association of BMI with year 20 CAC became progressively U-shaped in subsequent examinations (years 10,15, and 20). To understand the deepening U shape, the authors modeled year 20 BMI and its history using 3 indices : year 0 BMI, linear slope of BMI during 20 years, and BMI fluctuation during 20 years. In models including these 3 terms, year 0 BMI was associated positively with CAC, as was BMI fluctuation. However, adjusted odds ratios across quintiles of BMI slope (vs. the lowest quintile) were 0.7,0.4,0.5, and 0.4 (Ptrend
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