| Titre : | Circulating 25-Hydroxyvitamin D and Risk of Pancreatic Cancer : Cohort Consortium Vitamin D Pooling Project of Rarer Cancers : Anticancer Vitamins du Jour : The ABCED's So Far. (2010) |
| Auteurs : | Rachael-Z STOLZENBERG-SOLOMON ; Demetrius ALBANES ; Alan-A ARSLAN ; Sandra CLIPP ; . DAI QI ; Chinonye HARVEY ; Richard HAYES ; Kathy-J HELZLSOUER ; Ronald-L HORST ; Lonn IRISH ; Eric-J JACOBS ; . KAI YU ; Karen KOENIG ; Laurence-N KOLONEL ; Loic LE MARCHAND ; Marjorie-L MCCULLOUGH ; Alpa-V PATEL ; Mark-P PURDUE ; . QIUYIN CAI ; Xiao-Ou SHU ; Kirk SNYDER ; Jarmo VIRTAMO ; . WEI ZHENG ; Stephanie-J WEINSTEIN ; Lynn-R WILKINS ; Anne ZELENIUCH-JACQUOTTE ; Department of Environmental Medicine. School of Medicine. New York University. New York. NY. USA ; Division of Epidemiology. Department of Medicine. Vanderbilt Epidemiology Center. Vanderbilt-Ingram Cancer Center. School of Medicine. Vanderbilt University. Nashville. TN. USA ; Epidemiology Program. Cancer Research Center. University of Hawaii. Honolulu. HI. USA ; Information Management Services Inc. Silver Spring. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 172, n° 1, 2010) |
| Pagination : | 81-93 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Facteur risque ; Risque ; Vitamine D ; Enquête cas témoin ; Epidémiologie ; Etude prospective |
| Résumé : | [BDSP. Notice produite par INIST-CNRS mER0x9A8. Diffusion soumise à autorisation]. Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25 (OH) D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether pre-diagnostic circulating 25 (OH) D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n=1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-body mass index-and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25 (OH) D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25 (OH) D status. However, a high 25 (OH) D concentration (>=100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio=2.12,95% confidence interval : 1.23,3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered. |
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