| Titre : | Circulating 25-Hydroxyvitamin D and Risk of Epithelial Ovarian Cancer : Cohort Consortium Vitamin D Pooling Project of Rarer Cancers : Anticancer Vitamins du Jour : The ABCED's So Far. (2010) |
| Auteurs : | . WEI ZHENG ; Alan-A ARSLAN ; Kim-N DANFORTH ; Yu-Tang GAO ; Marc-T GOODMAN ; Susan-E HANKINSON ; Chinonye HARVEY ; Richard-B HAYES ; Kathy-J HELZLSOUER ; Brian-E HENDERSON ; Ronald-L HORST ; . KAI YU ; Laurence-N KOLONEL ; Marjorie-L MCCULLOUGH ; Alpa-V PATEL ; Mark-P PURDUE ; Xiao-Ou SHU ; Kirk SNYDER ; Emily STEPLOWSKI ; Shelley-S TWOROGER ; Kala VISVANATHAN ; Stephanie-J WEINSTEIN ; Anne ZELENIUCH-JACQUOTTE ; Information Management Services. Inc. Silver Spring. MD. USA ; New York University Cancer Institute. New York. NY. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 172, n° 1, 2010) |
| Pagination : | 70-80 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Facteur risque ; Risque ; Vitamine D ; Enquête cas témoin ; Epidémiologie ; Ovaire ; Etude prospective |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0x8HAJA. Diffusion soumise à autorisation]. A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. However, few studies have examined the association of circulating 25-hydroxyvitamin D (25 (OH) D), an integrated measure of vitamin D status, with ovarian cancer risk. A nested case-control study was conducted among 7 prospective studies to evaluate the circulating 25 (OH) D concentration in relation to epithelial ovarian cancer risk. Logistic regression models were used to estimate odds ratios and 95% confidence intervals among 516 cases and 770 matched controls. Compared with 25 (OH) D concentrations of 50-<75 nmol/L, no statistically significant associations were observed for<37.5 (odds ratio (OR)=1.21,95% confidence interval (CI) : 0.87,1.70), 37.5-<50 (OR=1.03,95% CI : 0.75,1.41), or>=75 (OR=1.11,95% CI : 0.79,1.55) nmol/L. Analyses stratified by tumor subtype, age, body mass index, and other variables were generally null but suggested an inverse association between 25 (OH) D and ovarian cancer risk among women with a body mass index of>=25 kg/m2 (interaction<0.01). In conclusion, this large pooled analysis did not support an overall association between circulating 25 (OH) D and ovarian cancer risk, except possibly among overweight women. |
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