Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xtF8l8. Diffusion soumise à autorisation]. Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between circulating 25-hydroxyvitamin D (25 (OH) D) and kidney cancer within a large, nested case-control study developed as part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25 (OH) D were measured from 775 kidney cancer cases and 775 age-sex-race-and season-matched controls from 8 prospective cohort studies. Overall, neither low nor high concentrations of circulating 25 (OH) D were significantly associated with kidney cancer risk. Although the data showed a statistically significant decreased risk for females (odds ratio=0.31,95% confidence interval : 0.12,0.85) with 25 (OH) D concentrations of>=75 nmol/L, the linear trend was not statistically significant and the number of cases in this category was small (n=14). The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically.
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