Résumé :
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[BDSP. Notice produite par INIST-CNRS k9R0xosk. Diffusion soumise à autorisation]. Body fatness at young ages may be related to breast cancer risk independently of adult adiposity. The authors conducted a prospective analysis among 188,860 women (7,582 breast cancer cases) in the Nurses'Health Study (1988-2004) and Nurses'Health Study II (1989-2005) who recalled their body fatness at ages 5,10, and 20 years using a 9-level pictogram (level 1 : most lean ; level 9 : most overweight). Body fatness at young ages was inversely associated with risk of both premenopausal and postmenopausal breast cancer (per 1-unit increase in adolescent body fatness, relative risk (FIR)=0.88 and RR=0.91, respectively ; Ptrend3.9 kg) (per 1-unit increase, RR=0.89 and RR=0.94, respectively ; Pinteraction=0.04) and stronger for estrogen receptor-negative tumors than for estrogen receptor-positive tumors (per 1-unit increase, RR=0.86 and RR=0.92, respectively ; Pheterogeneity=0.03). Body fatness at young ages has a strong and independent inverse relation to breast cancer risk throughout life.
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