Résumé :
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[BDSP. Notice produite par INIST-CNRS cR0xVNcr. Diffusion soumise à autorisation]. Studies of the association between alcohol drinking and breast cancer show a tendency towards an increase in risk for high consumption levels but yield less consistent results for low-to-moderate levels, particularly among premenopausal women. In a population-based case-control study in Germany, the authors determined the effect of alcohol consumption at low-to-moderate levels on breast cancer risk among women up to age 50 years. The study included 706 case women whose breast cancer had been newly diagnosed in 1992-1995 and 1,381 residence-and age-matched controls. In multivariate conditional logistic regression analysis, the adjusted odds ratios for breast cancer were 0.71 (95% confidence interval (Cl) : 0.54,0.91) for average ethanol intake of 1-5 g/day, 0.67 (95% Cl : 0.50,0.91) for intake of 6-11 g/day, 0.73 (95% Cl : 0.51,1.05) for 12-18 g/day, 1.10 (95% Cl : 0.73,1.65) for 19-30 g/day, and 1.94 (95% Cl : 1.18,3.20) for>31 g/day. The association with high daily ethanol intake of>=19 g was modified by educational level, such that odds ratios were 3.7,1.6, and 0.7 for women with low, moderate, and high levels of education, respectively. These data suggest that low-level consumption of alcohol does not increase breast cancer risk in premenopausal women.
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