Résumé :
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[BDSP. Notice produite par INIST-CNRS XR0xS81x. Diffusion soumise à autorisation]. Context Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the United States occurred concurrently with that of human immunodeficiency virus (HIV), but there have been no direct measurements of KSHV prevalence at the beginning of the HIV epidemic. Objectives To determine the prevalence of KSHV infection in homosexual men in San Francisco, Calif, at the beginning of the HIV epidemic in 1978 and 1979 and to examine changes in prevalence of KSHV at time points from 1978 through 1996 in light of changes in sexual behavior. Design, Setting, and Participants Analysis of a clinic-based sample (n=398) derived from the San Francisco City Clinic Cohort (ages 18-66 years) (n=2666 for analyses herein) and from population-based samples from the San Francisco Men's Health Study (MHS) (ages 25-54 years) (n=825 and 252) and the San Francisco Young Men's Health Study (YMHS) (ages 18-29 years) (n=428-976, and 557) ; behavioral studies were longitudinal and KSHV prevalence studies were cross-sectional. Main Outcome Measures Antibodies against KSHV and HIV ; sexual behaviors. Results The prevalence of KSHV infection in 1978 and 1979 was 26.5% of 235 (a random sample) overall (weighted for HIV infection) vs 6.9% (128/1842) for HIV in the San Francisco City Clinic Cohort sample. The prevalence of KSHV infection remained essentially unchanged between an MHS sample of 252 in 1984 and 1985 (29.6%) and a YMHS sample of 557 in 1995 and 1996 (26.4%), while HIV prevalence dropped from 49.5% of 825 in 1984 and 1985 (MHS) to 17.6% of 428 in 1992 and 1993 (YMHS). (...)
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