Titre :
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Strenuous physical labor is important as a cause of elevated alanine aminotransferase levels in Japanese patients with chronic hepatitis C viremia. (2005)
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Auteurs :
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Norihiko KUBO ;
Norihiro FURUSYO ;
Jun HAYASHI ;
Kenichiro KASHIWAGI ;
Hisashi NAKASHIMA ;
Kyushu University Hospital. Department of General Medicine. Fukuoka. JPN ;
Kyushu University. Faculty of Medical Sciences. Department of Environmental Medicine and Infectious Diseases. Fukuoka. JPN
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 20, n° 3, 2005)
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Pagination :
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251-261
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Langues:
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Anglais
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Mots-clés :
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Hépatite virale C
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Virose
;
Infection
;
Travail
;
Ouvrier
;
Tabagisme
;
Facteur
;
Alanine aminotransférase
;
Aminotransférase
;
Enzyme
;
Epidémiologie
;
Japon
;
Asie
;
Homme
;
Malade
;
Boisson alcoolisée
;
Consommation
;
VHC
;
Virus
;
Condition vie
;
Appareil digestif [pathologie]
;
Foie [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST-CNRS yHPKR0xg. Diffusion soumise à autorisation]. To clarify the influence of lifestyle habits on the elevated alanine aminotransferase (ALT) levels deterioration of Japanese patients with chronic hepatitis C virus (HCV) viremia, we investigated the effects of smoking, drinking, and physical labor on the disease course of the residents living in a rural area of Kyushu, Japan. The data of patients with chronic HCV viremia and control subjects without HCV infection were analyzed retrospectively from 1986 to 1992 and prospectively from 1993 to 2000. In 2000, a questionnaire was given to 268 HCV-infected patients and 275 control subjects to survey for the lifestyle habits. The data of serial ALT level testing during the observation period was used as a measure of liver damage : 183 HCV patients (68.3%) and 10 control subjects (3.6%) had abnormal ALT levels greater than 35 IU/l for more than half of their observation period. The percentage of HCV patients with elevated ALT levels significantly increased with the daily consumption of alcohol (p
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