Titre :
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Keeping America Healthy : CDC Prevention Research Partnerships. The National Birth Defects Prevention Study. (2001)
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Auteurs :
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P.W. YOON ;
M. ANDERKA ;
P.A. BOMITTI ;
S.L. CABMICHAEL ;
P. COSTA ;
Lynda-S DOLL, éd. ;
C. DRUSCHEL ;
L.D. EDMONDS ;
C.A. HOBBS ;
P.H. LANGLOIS ;
M.C. LYNBERG ;
C.A. MOORE ;
S.A. RASMUSSEN ;
Susan-C SCRIMSHAW, éd. ;
State Services Section. With the National Center on Birth Defects and Developmental Disabilities. Centers for Disease Control and Prevention Cdc Atlanta. GA. USA
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Type de document :
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Article
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Dans :
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Public health reports (vol. 116, 2001)
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Pagination :
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32-40
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Langues:
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Anglais
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Mots-clés :
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Malformation
;
Naissance
;
Enfant
;
Homme
;
Hérédité
;
Epidémiologie
;
Prévention santé
;
Maladie congénitale
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Résumé :
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[BDSP. Notice produite par INIST-CNRS 6LyR0xzW. Diffusion soumise à autorisation]. The National Birth Defects Prevention Study was designed to identify infants with major birth defects and evaluate genetic and environmental factors associated with the occurrence of birth defects. The ongoing case-control study covers an annual birth population of 482,000 and incluces cases dentifiec from birth defect surveillance registries in eight states. Infants used as controls are randomly selected from birth certificates or birth hospital records Mothers of case and control nfants are interviewed and parects are asked to collectibuccal ceils from themselves and their infants for DNA testing, information gathered from the interviews and the DNA specimens with be used to study independent genetic and environmental factors and geneenvironment interactions for a broad range of birth defects. As of December 2000,7470 cases and 3821 controls nad been ascertained n the eight states Interviews had been completed with 70% of the eligible case and contro mothers, buccal cell collection had begun in all of the study sites, and researchers were developing analysis plans for the compilec cata This study is the largest and broadest collaborative effort even conducted among the nation's eading birth defect researchers. The unprecedented statistical power that will resuit from this study will enable scientists to study the epidemiology of some rare birth defects for the first time. The compiled interview cata and banked DNA of approximately 35 categories of birth defects will facilitate future research as new hypotheses and improved technologies emerge.
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