Résumé :
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[BDSP. Notice produite par INIST-CNRS CR0xEBp9. Diffusion soumise à autorisation]. Although alcohol is a recognized teratogen, evidence is limited on alcohol intake and oral cleft risk. The authors examined the association between maternal alcohol consumption and oral clefts in a national, population-based case-control study of infants born in 1996-2001 in Norway. Participants were 377 infants with cleft lip with or without cleft palate, 196 with cleft palate only, and 763 controls. Mothers reported first-trimester alcohol consumption in self-administered questionnaires completed within a few months after delivery. Logistic regression was used to calculate odds ratios and 95% confidence intervals, adjusting for confounders. Compared with nondrinkers, women who reported binge-level drinking (>5 drinks per sitting) were more likely to have an infant with cleft lip with or without cleft palate (odds ratio=2.2,95% confidence interval : 1.1,4.2) and cleft palate only (odds ratio=2.6,95% confidence interval : 1.2,5.6). Odds ratios were higher among women who binged on three or more occasions : odds ratio=3.2 for cleft lip with or without cleft palate (95% confidence interval : 1.0,10.2) and odds ratio=3.0 for cleft palate only (95% confidence interval : 0.7,13.0). Maternal binge-level drinking may increase the risk of infant clefts.
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