Titre : | Female Reproductive Factors, Gene Polymorphisms in the Estrogen Metabolism Pathway, and Risk of Lung Cancer in Chinese Women. (2012) |
Auteurs : | Wei-Yen LIM ; Philip ENG ; . KHOON LEONG CHUAH ; Elaine LIM ; Alan NG ; Agus SALIM ; Adeline SEOW ; . SWAN SWAN LEONG ; Augustine TEE ; Ming TEH ; . TOW KEANG LIM ; . WEE TENG POH ; . YING CHEN ; Department of Respiratory and Critical Care Medicine. Tan Tock Seng Hospital. Singapore. SGP ; Saw Swee Hock School of Public Health. National University of Singapore. Singapore. SGP |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 175, n° 6, 2012) |
Pagination : | 492-503 |
Langues: | Anglais |
Mots-clés : | Femme ; Reproduction ; Gène ; Génétique ; Métabolisme ; Facteur risque ; Risque ; Chine ; Etiologie ; Historique ; Histoire ; Epidémiologie ; Asie ; Homme ; Cancer |
Résumé : | [BDSP. Notice produite par INIST-CNRS JR0xG898. Diffusion soumise à autorisation]. The authors examined relations between reproductive factors and 5 estrogen pathway gene polymorphisms (CYP17 rs743572, CYP19A1 rs10046, ERbêta rs1256049, ERbêta rs4986938, and COMTrs4680) among 702 Singapore Chinese female lung cancer cases and 1,578 hospital controls, of whom 433 cases (61.7%) and 1,375 controls (87.1%) were never smokers. Parity (per child, odds ratio (OR)=0.92,95% confidence interval (CI) : 0.87,0.97) and menstrual cycle length (for>30 days vs.=31 years vs.52 years vs.=40 years vs. |