Titre : | Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer : A Cohort-nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition. (2012) |
Auteurs : | Anke-M LEUFKENS ; Krasimira ALEKSANDROVA ; Naomi-E ALLEN ; Eva ARDANAZ ; Marcial ARGUELLES ; Heiner BOEING ; Marie-Christine BOUTRON-RUAULT ; Hbas BUENO-DE-MESQUITA ; Francoise CLAVEL-CHAPELON ; Francesca-L CROWE ; Vardis DILIS ; Miren DORRONSORO ; Veronika FEDIRKO ; Carlos-A GONZALEZ ; Goran HALLMANS ; Jose-Maria HUERTA ; Eugene-Hjm JANSEN ; Mazda JENAB ; Rudolf KAAKS ; Kay-Tee KHAW ; Annekatrin LUKANOVA ; Sophie MOROIS ; Teresa NORAT ; Anja OLSEN ; Kim OVERVAD ; Valeria PALA ; Domenico PALLI ; Richard PALMQVIST ; Salvatore PANICO ; Petra-H PEETERS ; Tobias PISCHON ; Elio RIBOLI ; Maria-José SANCHEZ ; Peter-D SIERSEMA ; Guri SKEIE ; Anne TJONNELAND ; Dimitrios TRICHOPOULOS ; Antonia TRICHOPOULOU ; Rosario TUMINO ; Fränzel-Jb VAN DUIJNHOVEN ; Paolo VINEIS ; Nick WAREHAM ; Sjoukje-Hs WOUDT ; Department of Gastroenterology and Hepatology. University Medical Center. Utrecht. NLD ; Institut National de la Sante et de la Recherche Médicale. Centre for Research in Epidemiology and Population Health. U1018. Institut Gustave-Roussy. Villejuif. FRA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 175, n° 7, 2012) |
Pagination : | 653-663 |
Langues: | Anglais |
Mots-clés : | Cancer ; Facteur risque ; Risque ; Enquête cas témoin ; Epidémiologie ; Europe ; Etude prospective ; Alimentation ; Nutrition |
Résumé : | [BDSP. Notice produite par INIST-CNRS nCmJR0xn. Diffusion soumise à autorisation]. Oxidative stress has been shown to play an important role in carcinogenesis, but prospective evidence for an association between biomarkers of oxidative stress and colorectal cancer (CRC) risk is limited. The authors investigated the association between prediagnostic serum levels of oxidative stress indicators (i.e., reactive oxygen metabolites (ROM) and ferric reducing ability of plasma (FRAP)) and CRC risk. This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). Incidence rate ratios and 95 % confidence intervals were calculated using conditional logistic regression analyses. ROM were associated with overall CRC risk (highest tertile vs. lowest : adjusted incidence rate ratio (IRRadj)=1.91,95 % confidence interval (CI) : 1.47,2.48), proximal (IRRadj =1.89,95 % CI : 1.06,3.36) and distal (IRRadj =2.31,95 % CI : 1.37,3.89) colon cancer, and rectal cancer (IRRadj =1.69,95 % CI : 1.05,2.72). When results were stratified by tertile of follow-up time, the association remained significant only in participants with less than 2.63 years of follow-up (IRRadj =2.28,95 % CI : 1.78,2.94 ; P-heterogeneity |