Résumé :
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[BDSP. Notice produite par INIST-CNRS HlJoR0xF. Diffusion soumise à autorisation]. Objectives. We sought to identify predictors of lead concentrations in the blood, tibias, and patellae of older adults and to describe differences by gender, race/ethnicity, and other factors that can influence lead toxicokinetics and, thus modify health effects. Methods. Participants aged 50 to 70 years (N=1140) were randomly identified from selected neighborhoods in Baltimore, Maryland. We measured lead concentrations by anodic stripping voltammetry (in blood) and 109Cd-induced K-shell x-ray fluorescence (in bone). We used multiple linear regression to identify predictors of lead concentrations. Results. Mean (SD) lead concentrations in blood, tibias, and patellae were 3.5 (2.4) (mug/dL, 18.9 (12.5) mug/g, and 6.8 (18.1) mug/g, respectively. Tibia concentrations were 29% higher in African Americans than in Whites (P<. we observed effect modification by race on the association of gender and physical activity to blood lead concentrations age tibia concentrations. patella differed apolipoprotein e genotype modified this relation. conclusions. african americans evidenced a prominent disparity in lifetime dose. women may be at higher risk release from bone consequent health effects because increased demineralization with aging.>
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