Résumé :
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[BDSP. Notice produite par INIST-CNRS R0x77ttZ. Diffusion soumise à autorisation]. We examined the association of serum uric acid (SUA) with development of hypertension (blood pressure>=140/90 mm Hg and/or medication for hypertension) and impaired fasting glucose (IFG) (a fasting plasma glucose level 6.1-6.9 mmol/l) or Type II (non-insulin-dependent) diabetes (a fasting plasma glucose level>=7.0 mmol/l and/or medication for diabetes) over a 6-year follow-up among 2310 Japanese male office workers aged 35-59 years who did not have hypertension, IFG, Type II diabetes, or past history of cardiovascular disease at study entry. After controlling for potential predictors of hypertension and diabetes, the relative risk for hypertension compared with quintile 1 of SUA level was 1.27 [95% confidence interval (CI) : 1.00-1.62] for quintile 2,1.34 (95% CI : 1.08-1.74) for quintile 3,1.48 (95% CI : 1.18-1.89) for quintile 4, and 1.58 (95% CI : 1.26-1.99) for quintile 5 (p for trend=24.2 kg/m2, although the absolute risk was greater in more obese men. These results indicate that SUA level is closely associated with an increased risk for hypertension and IFG or Type II diabetes.
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