Titre : | On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies. Commentary. (2007) |
Auteurs : | Muin-J KHOURY ; H. CAMPBELL, disc. ; Marta GWINN ; IOANNIDIS (John-Pa) : GRC. Department of Hygiene and Epidemiology University of loannina School of Medicine. Ioannina. ; LITTLE (Julian) : CAN. Canada Research Chair in Human Genome Epidemiology. Department of Epidemiology and Community Medicine. University of Ottawa. Ottawa. ; T. MANOLIO, disc. ; University of Edinburgh. Public Health Sciences. Division of Community Health Sdences. Edinburgh. GBR ; University of Ottawa. Centers for Disease Control and Prevention. Coordinating Center for Health Promotion. National Office of Public Health Genomics. Ottawa. CAN |
Type de document : | Article |
Dans : | International journal of epidemiology (vol. 36, n° 2, 2007) |
Pagination : | 439-448 |
Langues: | Anglais |
Mots-clés : | Homme ; Pathologie ; Epidémiologie ; Méthodologie ; Facteur risque |
Résumé : | [BDSP. Notice produite par INIST-CNRS 8VAGR0xZ. Diffusion soumise à autorisation]. Emerging technologies are allowing researchers to study hundreds of thousands of genetic variants simultaneously as risk factors for common complex diseases. Both theoretical considerations and empirical evidence suggest that specific genetic variants causally associated with common diseases will have small effects (risk ratios mostly |