Titre : | A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries : The diabetes heart study. (2007) |
Auteurs : | Lynne-E WAGENKNECHT ; BOWDEN (Donald-W) : USA. Department of Biochemistry. Wake Forest University School of Medicine. Winston Salem. NC. ; CARR (Jjeffery) : USA. Division of Radiologic Sciences. Wake Forest University School of Medicine. Winston Salem. NC. ; FREEDMAN (Barry-I) : USA. Department of Medicine. Wake Forest University School of Medicine. Winston Salem. NC. ; Carl-D LANGEFELD ; Wake Forest University. School of Medicine. Division of Public Health Sciences. Winston Salem. NC. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 166, n° 3, 2007) |
Pagination : | 340-347 |
Langues: | Anglais |
Mots-clés : | Diabète ; Artériosclérose ; Etude comparée ; Facteur risque ; Coeur ; Fratrie ; Epidémiologie ; Homme ; Etats Unis ; Amérique ; Appareil circulatoire [pathologie] ; Vaisseau sanguin [pathologie] ; Appareil cardiovasculaire ; Vaisseau ; Glande endocrine [pathologie] ; Amérique du Nord |
Résumé : | [BDSP. Notice produite par INIST-CNRS R0x7GK3c. Diffusion soumise à autorisation]. The extent of shared risk factors for calcified atherosclerotic plaque (CAP) of the coronary, carotid, and abdominal aortic arteries is unknown. CAP was measured by computed tomography in 1,125 individuals in families affected with diabetes. Statistical methods adjusted for the lack of independence between observations. CAP scores were standardized, and tests of interaction were conducted to compare risk factor relations across vascular beds. The average age of the cohort was 61 years, and 84% had diabetes. The correlation in CAP scores across vascular beds ranged from 0.59 to 0.72. Age, albumin/creatinine ratio, hemoglobin A1c, diabetes, hypertension, and lipid-lowering therapy were correlated with quantity of CAP in all vascular beds (all p |