Résumé :
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[BDSP. Notice produite par INIST-CNRS YXKJR0x7. Diffusion soumise à autorisation]. Background Cervical cancer is the most common cancer in women in Mali and the second commonest cause of cancer mortality. Methods As part of an international effort to evaluate the role of human papillomavirus (HPV) in the aetiology of cervical cancer, we conducted a hospital-based case-control study in three medical centres in Bamako during 1994-1995. A total of 82 cases (invasive cervical cancer patients) and 97 controls matched to the cases for age were included. Information on risk factors was collected through personal interview. Serum antibodies to HPV 16,18 and 31 virus like particles (VLP) were detected using ELISA assays. Polymerase chain reaction was used to detect HPV DNA in frozen biopsies of cases. Results Human papillomavirus 6,18,31 VLP were detected in 60.4% of cases and 45.4% of controls (P=0.03). Overall, HPV DNA was identified in 96.9% of the cervical cancer cases. Risk factors for cervical cancer were parity>10 versus
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