Titre :
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Familial history, age and smoking are important risk factors for disc degeneration disease in Arabic pedigrees. (2001)
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Auteurs :
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Gregory LIVSHITS ;
Z.V.I. COHEN ;
Orabi HIGLA ;
Konstantin YAKOVENKO ;
Department of Anatomy and Anthropology. Sackler Faculty of Medicine. Tel Aviv University. Tel Aviv. ISR ;
Department of Traumatology and Orthopaedics "A". Ichilov Municipal Hospital. Tel Aviv. ISR
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 17, n° 7, 2001)
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Pagination :
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643-651
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Langues:
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Anglais
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Mots-clés :
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Hernie
;
Hernie discale
;
Disque intervertébral
;
Génétique
;
Maladie héréditaire
;
Famille
;
Age
;
Tabagisme
;
Epidémiologie
;
Facteur risque
;
Homme
;
Israël
;
Asie
;
Système ostéoarticulaire [pathologie]
;
Rachis [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST-CNRS nxNR0x66. Diffusion soumise à autorisation]. The present study used computed tomography imaging to evaluate the extent and pattern of the intergenerational transmission of spinal disc degeneration disease (DDD) in complex pedigrees. Contribution of a number of the potential covariates was also studied using univariate and multivariate logistic regression analysis, as well as two types of complex segregation analysis models. Among 161 individuals studied, DDD was diagnosed in 60 individuals. The number of protruded discs varied from 1 to 4, mostly in lumbar or lumbosacral regions. The average age at onset of the disease was similar for both women (36.0 years) and men (34.8 years). The proportion of the individuals affected by the DDD status of their parents ranged from 10% in families of two healthy parents to 55.5% of two affected parents (p
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