Titre :
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Exposure to fine particulate matter and acute effects on blood pressure : effect modification by measures of obesity and location. (2010)
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Auteurs :
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S. KANNAN ;
J.T. DVONCH ;
J. HOUSE ;
B.A. ISRAEL ;
P. MAX ;
G. MENTZ ;
A.G. REYES ;
A.J. SCHULZ ;
Department of Health Behavior and Health Education. University of Michigan School of Public Health. Ann Arbor. USA
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Type de document :
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Article
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Dans :
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Journal of epidemiology and community health (vol. 64, n° 1, Janvier 2010)
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Pagination :
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68-74
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Langues:
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Anglais
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Mots-clés :
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Exposition
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Obésité
;
Pollution atmosphérique
;
Pression artérielle
;
Modification
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Résumé :
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[BDSP. Notice produite par INIST-CNRS A8R0xHBk. Diffusion soumise à autorisation]. Background : Observational studies and controlled experiments have provided evidence that airborne particulate matter (PM) is capable of acutely increasing blood pressure (BP) in certain scenarios. The goal of this study was to evaluate whether and to what extent obesity and community location affect relationships between fine particulate matter (PM2.5) and blood pressure (BP) measures. Methods : Using data from a stratified random sample survey of adults conducted in 2002-3 in Detroit, Michigan, we tested body mass index (BMI) and waist circumference (WCIR) in separate models as effect modifiers of the relationship between PM2.5 exposure and BP. We also tested interactions with community location. Models were adjusted for covariates with established pro-hypertensive effects. Results : PM2.5 exposure was positively associated with increased pulse pressure (PP) for those categorised as obese (BMI>=30) across lags 2 (bêta 4.16, p=30) or with WCIR above high-risk cuts points. Conclusions : This community-based study suggests that positive associations between PM2.5 exposure and PP and systolic BP are enhanced in areas proximate to sources of PM 2.5 emissions. These patterns were observed for all residents, but were more visible and consistent among those who were obese. Research is needed to examine the mechanistic pathways by which air particles interact with obesity and location to affect BP, and inform community interventions to reduce the population burden of hypertension and related co-morbidities.
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